<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="letter" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JDERM</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Dermatol</journal-id>
      <journal-title>JMIR Dermatology</journal-title>
      <issn pub-type="epub">2562-0959</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v6i1e47252</article-id>
      <article-id pub-id-type="pmid">37843896</article-id>
      <article-id pub-id-type="doi">10.2196/47252</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Research Letter</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Research Letter</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Smartwatch Technology in Medicine: A Call for Future Dermatologic Research</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Dellavalle</surname>
            <given-names>Robert</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Ribeiro</surname>
            <given-names>Nuno</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Chu</surname>
            <given-names>Yuanchia</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Nelson</surname>
            <given-names>Emelie E</given-names>
          </name>
          <degrees>BS</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-6255-5111</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Rousseau</surname>
            <given-names>Morgan A</given-names>
          </name>
          <degrees>MD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7157-0639</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Black</surname>
            <given-names>T Austin</given-names>
          </name>
          <degrees>BS</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9685-5078</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>George</surname>
            <given-names>Mariya N</given-names>
          </name>
          <degrees>BSA</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-7957-8398</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Rashid</surname>
            <given-names>Rashid M</given-names>
          </name>
          <degrees>MD, PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <address>
            <institution>Mosaic Dermatology</institution>
            <addr-line>2211 Norfolk St</addr-line>
            <addr-line>Suite #405</addr-line>
            <addr-line>Houston, TX, 77098</addr-line>
            <country>United States</country>
            <phone>1 281 941 5556</phone>
            <email>rashidmdphd@gmail.com</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0003-9511-3517</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>McGovern Medical School at UTHealth Houston</institution>
        <addr-line>Houston, TX</addr-line>
        <country>United States</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Mosaic Dermatology</institution>
        <addr-line>Houston, TX</addr-line>
        <country>United States</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Rashid M Rashid <email>rashidmdphd@gmail.com</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2023</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>16</day>
        <month>10</month>
        <year>2023</year>
      </pub-date>
      <volume>6</volume>
      <elocation-id>e47252</elocation-id>
      <history>
        <date date-type="received">
          <day>13</day>
          <month>3</month>
          <year>2023</year>
        </date>
        <date date-type="rev-request">
          <day>29</day>
          <month>7</month>
          <year>2023</year>
        </date>
        <date date-type="rev-recd">
          <day>21</day>
          <month>9</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>25</day>
          <month>9</month>
          <year>2023</year>
        </date>
      </history>
      <copyright-statement>©Emelie E Nelson, Morgan A Rousseau, T Austin Black, Mariya N George, Rashid M Rashid. Originally published in JMIR Dermatology (http://derma.jmir.org), 16.10.2023.</copyright-statement>
      <copyright-year>2023</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Dermatology, is properly cited. The complete bibliographic information, a link to the original publication on http://derma.jmir.org, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://derma.jmir.org/2023/1/e47252" xlink:type="simple"/>
      <kwd-group>
        <kwd>digital health</kwd>
        <kwd>dermatology</kwd>
        <kwd>smartwatch</kwd>
        <kwd>ultraviolet radiation</kwd>
        <kwd>ultraviolet</kwd>
        <kwd>UV</kwd>
        <kwd>skin cancer</kwd>
        <kwd>pruritus</kwd>
        <kwd>sunscreen</kwd>
        <kwd>device</kwd>
        <kwd>support</kwd>
        <kwd>patient education</kwd>
        <kwd>clinical management</kwd>
        <kwd>cardiovascular</kwd>
        <kwd>cancer prevention</kwd>
        <kwd>prevention</kwd>
        <kwd>cancer</kwd>
        <kwd>technology</kwd>
        <kwd>wearable technology</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>The use of smartwatches and other wearable devices has been increasingly empowering users with the ability to monitor numerous critical aspects of their health. From monitoring heart rate and blood pressure to detecting arrhythmias, seizure activity, and falls, noninvasive smartwatch technology has proven to be an effective screening tool that can be used to inform patient care and improve outcomes [<xref ref-type="bibr" rid="ref1">1</xref>]. Additionally, smartwatches are highly portable, relatively affordable, and adequately available to the public, making them an attractive investment for consumers.</p>
      <p>The application of smartwatch technology to the field of dermatology has not been well described; however, smartwatch technology could greatly aid in both risk assessment and prevention of skin cancer. This paper examines smartwatch-associated research across all medical specialties and proposes future applications to dermatology, specifically for skin cancer prevention and intervention.</p>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <p>A review of the use of smartwatches across all medical specialties was performed. The search terms “smart watch” and “smartwatch” were searched in PubMed for English-language articles published from database inception to April 10, 2023. <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref> summarizes the inclusion and exclusion criteria. One reviewer (MAR) screened all articles for inclusion. Studies that satisfied the inclusion and exclusion criteria were included for data extraction. Two reviewers (MAR and TAB) independently performed the full-text review and data extraction, with the primary variable of interest being the medical specialty associated with each article.</p>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <p>Of the 1333 identified articles, 346 met the study eligibility criteria. <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref> displays the frequency of each medical specialty represented. The majority of studies examined smartwatches in the context of cardiovascular research (174/346, 50.4%). Neurology was represented in 15.1% (52/346) of the studies, and the remaining 34.5% (120/346) of studies were distributed across 12 other specialties.</p>
      <p>Only 3 studies (&#60;1%) represented dermatologic research (<xref ref-type="table" rid="table1">Table 1</xref>). One used wrist actigraphy to measure nocturnal scratching in patients with pruritus [<xref ref-type="bibr" rid="ref2">2</xref>]. The second, by Jang et al [<xref ref-type="bibr" rid="ref3">3</xref>], measured sleep duration and its impact on skin characteristics in women. Finally, Dey et al [<xref ref-type="bibr" rid="ref4">4</xref>] used smartwatches to track cumulative UV exposure in patients.</p>
      <table-wrap position="float" id="table1">
        <label>Table 1</label>
        <caption>
          <p>Summary of dermatology-related smartwatch studies.</p>
        </caption>
        <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="160"/>
          <col width="180"/>
          <col width="170"/>
          <col width="170"/>
          <col width="170"/>
          <col width="150"/>
          <thead>
            <tr valign="top">
              <td>Article (author, year, journal)</td>
              <td>Methods</td>
              <td>Feature of watch used</td>
              <td>Outcome studied</td>
              <td>Key findings</td>
              <td>Smartwatch used</td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td>Dey et al [<xref ref-type="bibr" rid="ref4">4</xref>], 2017, <italic>Eng Med Biol Soc</italic></td>
              <td>Integration of UV sensors into 1200 smartwatches and smartphones</td>
              <td>UV exposure</td>
              <td>Cumulative UV tracking</td>
              <td>Integration of UV sensors into these devices provided an accurate estimate of cumulative UV exposure</td>
              <td>Android</td>
            </tr>
            <tr valign="top">
              <td>Ikoma et al [<xref ref-type="bibr" rid="ref2">2</xref>], 2019, <italic>Acta Derm Venereol</italic></td>
              <td>Creation of a smartwatch app to detect nocturnal scratching using accelerometer data</td>
              <td>Wrist actigraphy</td>
              <td>Nocturnal scratching in patients with pruritus</td>
              <td>High reliability and clinical usefulness of the newly created app was demonstrated</td>
              <td>Apple</td>
            </tr>
            <tr valign="top">
              <td>Jang et al [<xref ref-type="bibr" rid="ref3">3</xref>], 2020, <italic>Skin Res Technol</italic></td>
              <td>Already existing sleep-tracking capabilities in smartwatches were used and longitudinally compared to the characteristics of skin aging among participants</td>
              <td>Sleep time monitoring</td>
              <td>Skin characteristics in women</td>
              <td>Negative changes were seen in the skin characteristics of patients who averaged less sleep</td>
              <td>Xiaomi</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>Great disparities exist in the use of smartwatch technology across various medical specialties. We propose this is in part due to the specialty-specific capabilities found within smartwatches. For example, the majority of included studies examined applications of smartwatch technology in cardiology, likely due to the device’s ability to measure pulse and respiration rate and perform electrocardiograms [<xref ref-type="bibr" rid="ref1">1</xref>].</p>
        <p>As smartwatches sit on the skin and are thus exposed to the same environmental factors as the wearer, they represent a valuable opportunity to better understand both the UV and non-UV environmental, occupational, and avocational exposures that may contribute to the development of skin cancer. With the incidence of both melanoma and keratinocyte carcinomas continuously increasing [<xref ref-type="bibr" rid="ref5">5</xref>], understanding the risk factors for the development of skin cancer becomes important for determining individual patient risk, early detection, and improving clinical outcomes. Furthermore, because smartwatches provide continuous monitoring capabilities, personalized alerts could be implemented to notify users of behavioral changes they could employ to reduce the risk of developing skin cancer (ie, “Your UV exposure over the last 7 days is higher than normal. To minimize cancer risk, ensure proper UV protection.”). Use of these continuous monitoring capabilities could be further applied to advance research within the field, allowing for minimally invasive yet highly accurate data collection, which can aid in the development of personalized treatment plans.</p>
        <p>Smartwatch technology continues to be refined and improved to better meet the health care needs of consumers. This is perhaps best exemplified by the development of smartwatch-based oxygen saturation measurement capabilities during the COVID-19 pandemic. We propose that future smartwatches be equipped with the technology to measure UV-A and UV-B rays, time spent in water, and air quality, as well as prompt users to reapply sunscreen at regular intervals. The benefits of these implementations are summarized in <xref ref-type="table" rid="table2">Table 2</xref>.</p>
        <p>The benefits of smartwatch technology in skin cancer prevention and intervention are numerous. However, it must be acknowledged that smartwatches can be costly and not accessible to everyone. As such, the quantifiable and generalizable impact of this technology may be somewhat diminished.</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Dermatological applications and benefits of smartwatches.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="250"/>
            <col width="250"/>
            <col width="250"/>
            <col width="250"/>
            <thead>
              <tr valign="top">
                <td>Intervention</td>
                <td>Mechanism</td>
                <td>Effect</td>
                <td>Special populations of benefit</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>UV sensor and sunscreen reminder</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Provide individuals with a quantitative, cumulative estimate of UV exposure</p>
                    </list-item>
                    <list-item>
                      <p>Remind individuals at appropriate intervals to reapply sunscreen</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Encourage individuals to reapply sunscreen at regular intervals and to limit time spent outdoors during high UV-index hours</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Patients with xeroderma pigmentosum, porphyrias, photoallergy, lupus erythematosus, and other photosensitivity disorders</p>
                    </list-item>
                    <list-item>
                      <p>Individuals who are occupationally or recreationally exposed to the sun</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Time spent in water monitor</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Provide individuals with quantitative estimates of total time spent in water</p>
                    </list-item>
                    <list-item>
                      <p>Remind individuals at appropriate intervals to reapply sunscreen</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Encourage reapplication of sunscreen</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Patients with conditions exacerbated by water such as aquagenic keratoderma</p>
                    </list-item>
                    <list-item>
                      <p>Swimmers, surfers, and divers</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Air quality</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Alert individuals to chemical hazards, pollen levels, or other irritating substances in the atmosphere</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Promote the use of protective clothing, sunscreen with topical antioxidants, and the usage of indoor air purifiers or ventilators</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Individuals with atopic conditions</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
        <title>Conclusion</title>
        <p>A significant gap in the medical literature exists surrounding the potential uses of smartwatches in the field of dermatology. Nonetheless, the application of smartwatches within dermatology represents a point of meaningful implication, especially as it relates to skin cancer prevention and intervention. As such, future research on smartwatch technology in dermatology is warranted.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Inclusion and exclusion criteria for study eligibility.</p>
        <media xlink:href="derma_v6i1e47252_app1.docx" xlink:title="DOCX File , 7 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Representation of smartwatch-related clinical research among all medical specialties.</p>
        <media xlink:href="derma_v6i1e47252_app2.png" xlink:title="PNG File , 148 KB"/>
      </supplementary-material>
    </app-group>
    <ack>
      <p>This research did not receive any specific grants from funding agencies in the public, commercial, or not-for-profit sectors.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Reeder</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>David</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Health at hand: a systematic review of smart watch uses for health and wellness</article-title>
          <source>J Biomed Inform</source>
          <year>2016</year>
          <month>10</month>
          <volume>63</volume>
          <fpage>269</fpage>
          <lpage>276</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://linkinghub.elsevier.com/retrieve/pii/S1532-0464(16)30113-7"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.jbi.2016.09.001</pub-id>
          <pub-id pub-id-type="medline">27612974</pub-id>
          <pub-id pub-id-type="pii">S1532-0464(16)30113-7</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ikoma</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Ebata</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Chantalat</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Takemura</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Mizzi</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Poncet</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>LeClercq</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>Measurement of nocturnal scratching in patients with pruritus using a smartwatch: initial clinical studies with the Itch Tracker app</article-title>
          <source>Acta Derm Venereol</source>
          <year>2019</year>
          <month>03</month>
          <day>01</day>
          <volume>99</volume>
          <issue>3</issue>
          <fpage>268</fpage>
          <lpage>273</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.2340/00015555-3105"/>
          </comment>
          <pub-id pub-id-type="doi">10.2340/00015555-3105</pub-id>
          <pub-id pub-id-type="medline">30523352</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Jang</surname>
              <given-names>SI</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Han</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>AR</given-names>
            </name>
            <name name-style="western">
              <surname>An</surname>
              <given-names>JS</given-names>
            </name>
            <name name-style="western">
              <surname>Park</surname>
              <given-names>JO</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>BJ</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>A study of skin characteristics with long-term sleep restriction in Korean women in their 40s</article-title>
          <source>Skin Res Technol</source>
          <year>2020</year>
          <month>03</month>
          <day>06</day>
          <volume>26</volume>
          <issue>2</issue>
          <fpage>193</fpage>
          <lpage>199</lpage>
          <pub-id pub-id-type="doi">10.1111/srt.12797</pub-id>
          <pub-id pub-id-type="medline">31692145</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Dey</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Sahoo</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Agrawal</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Mondal</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Bhowmik</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Tiwari</surname>
              <given-names>V</given-names>
            </name>
          </person-group>
          <article-title>Personalized cumulative UV tracking on mobiles &#38; wearables</article-title>
          <year>2017</year>
          <conf-name>39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society</conf-name>
          <conf-date>July 11-15</conf-date>
          <conf-loc>Jeju, South Korea</conf-loc>
          <fpage>2341</fpage>
          <lpage>2344</lpage>
          <pub-id pub-id-type="doi">10.1109/embc.2017.8037325</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Leiter</surname>
              <given-names>U</given-names>
            </name>
            <name name-style="western">
              <surname>Keim</surname>
              <given-names>U</given-names>
            </name>
            <name name-style="western">
              <surname>Garbe</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>Epidemiology of skin cancer: update 2019</article-title>
          <source>Adv Exp Med Biol</source>
          <year>2020</year>
          <volume>1268</volume>
          <fpage>123</fpage>
          <lpage>139</lpage>
          <pub-id pub-id-type="doi">10.1007/978-3-030-46227-7_6</pub-id>
          <pub-id pub-id-type="medline">32918216</pub-id>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
