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<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="letter" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JDERM</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Dermatol</journal-id>
      <journal-title>JMIR Dermatology</journal-title>
      <issn pub-type="epub">2562-0959</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v6i1e48669</article-id>
      <article-id pub-id-type="pmid">37874633</article-id>
      <article-id pub-id-type="doi">10.2196/48669</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Research Letter</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Research Letter</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Hell’s Itch: A Unique Reaction to UV Exposure</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Dellavalle</surname>
            <given-names>Robert</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Nigh</surname>
            <given-names>Andrew</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Alhanshali</surname>
            <given-names>Lina</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author">
          <name name-style="western">
            <surname>Ball</surname>
            <given-names>Katelin J</given-names>
          </name>
          <degrees>BS</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0002-8585-2095</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Muse</surname>
            <given-names>Brandon W</given-names>
          </name>
          <degrees>MS</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0005-3031-8006</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Cook</surname>
            <given-names>Bailey</given-names>
          </name>
          <degrees>MBA</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-6118-7871</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Quinn</surname>
            <given-names>Alyssa P</given-names>
          </name>
          <degrees>BS</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6299-3333</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Brooks</surname>
            <given-names>Benjamin D</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>College of Osteopathic Medicine</institution>
            <institution>Rocky Vista University</institution>
            <addr-line>255 E Center St</addr-line>
            <addr-line>Ivins, UT, 84738</addr-line>
            <country>United States</country>
            <fax>1 720 874 2452</fax>
            <phone>1 435 222 1236</phone>
            <email>bbrooks@rvu.edu</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-7456-3074</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>College of Osteopathic Medicine</institution>
        <institution>Rocky Vista University</institution>
        <addr-line>Ivins, UT</addr-line>
        <country>United States</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Benjamin D Brooks <email>bbrooks@rvu.edu</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2023</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>24</day>
        <month>10</month>
        <year>2023</year>
      </pub-date>
      <volume>6</volume>
      <elocation-id>e48669</elocation-id>
      <history>
        <date date-type="received">
          <day>2</day>
          <month>5</month>
          <year>2023</year>
        </date>
        <date date-type="rev-request">
          <day>26</day>
          <month>7</month>
          <year>2023</year>
        </date>
        <date date-type="rev-recd">
          <day>4</day>
          <month>9</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>15</day>
          <month>9</month>
          <year>2023</year>
        </date>
      </history>
      <copyright-statement>©Katelin J Ball, Brandon W Muse, Bailey Cook, Alyssa P Quinn, Benjamin D Brooks. Originally published in JMIR Dermatology (http://derma.jmir.org), 24.10.2023.</copyright-statement>
      <copyright-year>2023</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Dermatology, is properly cited. The complete bibliographic information, a link to the original publication on http://derma.jmir.org, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://derma.jmir.org/2023/1/e48669" xlink:type="simple"/>
      <abstract>
        <p>We present a survey-based exploration of Hell’s Itch, a severe dermatologic reaction often mistaken for sunburn, that reveals distinct symptoms including intense pain, unrelenting itching, paresthesia, and even suicidal ideation, differentiating it from a typical sunburn.</p>
      </abstract>
      <kwd-group>
        <kwd>Hell’s Itch</kwd>
        <kwd>social media</kwd>
        <kwd>sunburn</kwd>
        <kwd>sun</kwd>
        <kwd>survey</kwd>
        <kwd>skin</kwd>
        <kwd>dermatology</kwd>
        <kwd>dermatological</kwd>
        <kwd>itch</kwd>
        <kwd>itchiness</kwd>
        <kwd>itchy</kwd>
        <kwd>symptoms</kwd>
        <kwd>experience</kwd>
        <kwd>ultraviolet</kwd>
        <kwd>UV</kwd>
        <kwd>dermatologist</kwd>
        <kwd>teledermatology</kwd>
        <kwd>hair</kwd>
        <kwd>nails</kwd>
        <kwd>scratch</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>Hell’s Itch is an inciting dermatologic reaction that can occur after sun exposure and is often characterized by symptoms such as intense pain, itching, paresthesia, and suicidal ideation. A patient with Hell’s Itch described their experience as follows: “Dozens of white-hot sewing needles being repeatedly stabbed into my upper back. The pain is unrelenting and unbearable... It drives you completely insane.” Patient accounts like this distinguish Hell’s Itch from a typical sunburn.</p>
      <p>One in 3 people in the United States experience a sunburn annually [<xref ref-type="bibr" rid="ref1">1</xref>]. Sunburn is characterized by cutaneous erythema appearing 24 to 72 hours following sun exposure. The cause of sunburn is excessive exposure to UV radiation, commonly causing acute, transient inflammation in the skin [<xref ref-type="bibr" rid="ref2">2</xref>]. Symptoms depend on sunburn severity and may include blistering, peeling, and pruritus due to peeling [<xref ref-type="bibr" rid="ref2">2</xref>]. Like sunburn, Hell’s Itch is a manifestation of cutaneous damage after unprotected UV exposure. However, Hell’s Itch exhibits key differences in presentation. Hell’s Itch is reported as an acute, uncontrollable itch that causes stabbing pain when scratched [<xref ref-type="bibr" rid="ref3">3</xref>]. In addition, Hell’s Itch results from a key inciting event such as topical cream application or water exposure.</p>
      <p>Hell’s Itch is commonly misdiagnosed as sunburn. Misdiagnosis leads patients to seek medical advice from alternative sources such as social media. There are social media platforms with groups comprising up to 4000 members who share experiences and anecdotal treatment remedies.</p>
      <p>Here, we explore the differences in symptomatology between Hell’s Itch and a typical sunburn using a patient survey.</p>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <p>Hell’s Itch is not well characterized in the scientific literature, with only 3 published case reports to date [<xref ref-type="bibr" rid="ref3">3</xref>-<xref ref-type="bibr" rid="ref5">5</xref>]. Without objective diagnostic criteria available to establish a diagnosis of Hell’s Itch, our survey relied on subjective, self-reported data as the source to identify the distinguishing symptoms. We surveyed patients in social media groups with approximately 5500 total members to identify common symptoms, the incidence of symptoms, and symptom severity rated from 0 (none) to 10 (worst imaginable). Study inclusion criteria included adults aged ≥18 years with at least 1 episode of Hell’s Itch.</p>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <p>A total of 100 people with self-diagnosed Hell’s Itch completed the survey. The defining differences between the symptoms of Hell’s Itch and sunburn identified in the survey included unrelenting pruritus, intense pain, difficulty sleeping, paresthesia, and suicidal ideation (<xref ref-type="table" rid="table1">Table 1</xref>). Hell’s Itch symptoms commonly occurred after sun exposure and were often triggered by inciting events like water exposure (eg, showering, bathing, swimming, humidity, or sweating) or application of a topical cream (88/100, 88%).</p>
      <table-wrap position="float" id="table1">
        <label>Table 1</label>
        <caption>
          <p>Hell’s Itch survey results (N=100).</p>
        </caption>
        <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="330"/>
          <col width="340"/>
          <col width="330"/>
          <thead>
            <tr valign="bottom">
              <td>Symptom</td>
              <td>Prevalence (%)</td>
              <td>Average symptom severity rating<sup>a</sup></td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td>Pruritis</td>
              <td>98</td>
              <td>9.17</td>
            </tr>
            <tr valign="top">
              <td>Pain</td>
              <td>90</td>
              <td>8.42</td>
            </tr>
            <tr valign="top">
              <td>Difficulty sleeping</td>
              <td>87</td>
              <td>8.62</td>
            </tr>
            <tr valign="top">
              <td>Paresthesia or tingling</td>
              <td>77</td>
              <td>7.61</td>
            </tr>
            <tr valign="top">
              <td>Suicidal ideation</td>
              <td>44</td>
              <td>6.93</td>
            </tr>
            <tr valign="top">
              <td>Peeling skin</td>
              <td>33</td>
              <td>6.20</td>
            </tr>
            <tr valign="top">
              <td>Numbness</td>
              <td>13</td>
              <td>5.13</td>
            </tr>
            <tr valign="top">
              <td>Other</td>
              <td>32</td>
              <td>8.94</td>
            </tr>
          </tbody>
        </table>
        <table-wrap-foot>
          <fn id="table1fn1">
            <p><sup>a</sup>Symptom severity was rated from 0 (none) to 10 (worst imaginable).</p>
          </fn>
        </table-wrap-foot>
      </table-wrap>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <p>The incidence rate of Hell’s Itch is currently unknown as it is commonly misdiagnosed as a sunburn. Our survey characterizes the prevalence and severity of key symptoms differentiating Hell’s Itch from a typical sunburn—intense pain, itching, paresthesia, and even suicidal ideation—which are distinctive symptoms absent with sunburn. However, the survey may be limited in its strength because it relied on patients self-diagnosing their condition. Future efforts should move beyond convenience samples and include studies to characterize pathophysiology, risk factors, and effective treatments.</p>
    </sec>
  </body>
  <back>
    <app-group/>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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</article>
