Hidradenitis suppurativa (HS) is a chronic, suppurating inflammatory condition that characterizes the potential link between cutaneous and systemic disease. Currently, the underlying pathogenesis is unclear; however, follicular occlusion in the folliculopilosebaceous unit followed by follicular rupture and dysregulated immune response is widely proposed [1]. HS prevalence is 1%-4% worldwide and is higher in women [2].

Increasingly, evidence links HS, an inflammatory condition, with systemic comorbidities, such as cardiovascular disease, inflammatory bowel disease, diabetes mellitus, and depression [1]. A meta-analysis of more than 200,300 patients with HS found they had a higher prevalence of inflammatory arthritis, including spondyloarthritis and rheumatoid arthritis, than the general population [3]. Thus, this study investigated the prevalence of musculoskeletal (MSK) symptoms in patients with HS and associated factors.

The mean age of the 78 patients with HS was 37 (SD 12.2) years at recruitment and 23 (SD 12.1) years at symptom onset; 54% (42/78) were women and 46% (36/78) were men. Most participants identified as South Asian (n=23), White (n=19), or Black (n=14). There was a family history of HS in 14% (11/78) and of rheumatic disease in 53% (41/78) of participants. The most common comorbidities included depression (n=17) and arthritis (n=12) (Table 1).

Prolonged morning stiffness was reported by 24% (18/78) of participants, while a majority of reported arthralgia (41). In a multivariate regression, depression was significantly associated with prolonged morning stiffness (OR 6.1, 95% CI 1.4-26.1; P=.02), while female sex was significantly associated with arthralgia (OR 19.1, 95% CI 1.6-235.2; P=.02). Every patient with depression reported arthralgia (Table 2).

This cross-sectional study including 78 patients with HS demonstrates a significant association between MSK symptom severity, depression, and female sex. In a multivariate analysis, patients with depression had 6-fold greater odds of prolonged morning stiffness, while women had 19-fold greater odds of arthralgia. All patients with depression reported arthralgia.

A correlation between depression and HS has been reported [4]. The prevalence of depression in our study was 22% (17/78), comparable to 16.9% in a meta-analysis of 40,307 patients with HS [4]. World Health Organization survey data reported 69% of patients with depression present primarily with somatic symptoms, such as joint pain and back pain [5]. Proinflammatory cytokines tumor necrosis factor α (TNF-α), interleukin-1 β (IL-1β), and interleukin-10 (IL-10) are elevated in major depressive disorder [6] and HS [7], suggesting a possible pathophysiological process for increased inflammatory symptoms in comorbid patients. Alternatively, prolonged morning stiffness might limit activities of daily living, such as dressing and getting out of bed, leading to feelings of loss of independence and comorbid depression [8]. Women were more likely to report arthralgia, consistent with population-based findings of higher chronic MSK pain prevalence and inflammatory arthritis–associated pain [9] in women. Still, men may be more likely to have severe HS [10]. Further research into sex-based experiences of MSK symptoms in HS is recommended.

This cross-sectional study cannot show causality. Patients came from a single center, introducing possible selection bias. Associations between depression and arthralgia could not be assessed in the regression due to perfect correlation.

We highlight the importance of managing depression in patients with HS to lessen its potential effects on pain processing and worsened MSK symptoms. Larger cohort studies exploring the impacts of sex and depression on MSK symptoms are recommended.