The Government of India’s recent amendments to the Drugs and Magic Remedies Act proposed increased penalties for marketing and advertising skin fairness creams [1]. Yet, conventional Indian beauty standards still drive demand for skin-lightening products (SLPs) among women in India and transfeminine communities. Literature on skin-lightening practices among transgender people is limited. Transgender women undergoing estrogen therapy have an increased risk of melasma, which may be treated with skin-lightening agents like hydroquinone [2]. An ethnographic study of Indonesia’s transfeminine waria community found that members sought SLPs to feel more feminine and attract male attention [3]. Similar motivations were documented among Thailand’s transgender entertainers [4].

The Health Needs and Aesthetic Preferences Assessment of the Hyderabad Trans Community is a large study evaluating the social and health history of transgender and hijra women in India (N=300). As part of that study, we evaluated the prevalence of interest in skin-lightening treatments, the products used, and the financial costs involved.

An IRB addendum approved in December 2023 enabled 74.3% (223/300) of participants to respond to skin lightening–related questions. More than two-thirds (150/223, 67.3%) of respondents expressed interest in skin lightening, of whom 43.3% (65/150) used SLPs. The overall prevalence of SLPs among respondents was 29.1% (65/223). Further, 1.3% (2/150) of respondents used SLPs previously but lost interest, and 3.1% (7/223) could not recollect or identify the products they used. Money spent on skin lightening varied from ₹25 (US $0.30) to ₹70,000 (US $843; median ₹570 [US $7], IQR ₹2225 [US $27]). Patients sometimes used multiple products (Table 1).

Our study highlights the considerable interest in SLPs but marginally low prevalence of SLP use (likely due to financial barriers) among hijra and transgender women. Survey studies on cisgender populations in India indicate that SLPs have widespread prevalence (range 34%-60%) [5,6]. Deeply rooted cultural norms associate lighter skin with economic prosperity and beauty, leading to widespread use even among South Asian immigrant communities [7]. Although 67.3% of our respondents expressed interest in skin lightening, only 29.1% used SLPs—a lower rate than in cisgender communities. Within the colorism context, transfeminine individuals may view skin lightening as an accessible method for facilitating gender affirmation and social acceptance, as observed in other Asian countries.

Transgender women often face stigma and discrimination in health care settings, preventing them from seeking care [8]. Additionally, many transgender women in India engage in sex work, which acts a strong economic driver for investing in physical appearance (eg, undergoing skin treatments to achieve a desired aesthetic) [8]. Although many respondents were interested in skin lightening, less than half used SLPs, which included herbal mixtures from local shops and intravenous glutathione injections.

A study on SLPs used in India reported topical medication misuse prior to seeing a dermatologist [9]. The combination of hydroquinone, mometasone, and tretinoin cream is a common, over-the-counter melasma treatment in India [9]. Glutathione injections, though popular and expensive, have questionable efficacy [10]. Some alternative, traditional remedy–based medications are often cheaper. Popular marketed beauty creams use ingredients like kojic acid, niacinamide, and arbutin, which have been studied for their effects on skin pigmentation and complexion [11]. Chronic steroid use, while lightening some patients’ skin, may result in skin atrophy and other side effects [12]. Antifungal creams may treat pigmentary changes resulting from infections like pityriasis versicolor but have no additional lightening effects. Only 1 respondent reported using sunscreen daily, beyond sun protection factors in beauty creams.

Almost half of our respondents use medications with skin-lightening properties—mostly purchased over the counter. After the COVID-19 pandemic, the average hijra community member’s earnings decreased from US $7 to US $13 per day to less than US $2 per day [13]. Many members are of low socioeconomic status and have been reported to seek hormonal and surgical care from unqualified medical practitioners because allopathic treatments are costly [14]. Despite the Indian government’s regulatory efforts, interest in SLPs persists among transgender women [1]. However, only a fraction can afford to regularly use skin-lightening treatments. Given the potential health and financial risks, patient education about safe skin care is crucial for transgender women to make informed health decisions.

This study had several limitations, which we hope to address in follow-up studies. Participants’ informal occupations (eg, begging and sex work) precluded an accurate income assessment. Furthermore, the ad hoc survey lacked prior psychometric validation; this may have affected the accuracy of estimates regarding SLP use. Lastly, data on individual product costs and usage durations were not collected, limiting insights into the costs of long-term use.