<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="letter"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Dermatol</journal-id><journal-id journal-id-type="publisher-id">derma</journal-id><journal-id journal-id-type="index">29</journal-id><journal-title>JMIR Dermatology</journal-title><abbrev-journal-title>JMIR Dermatol</abbrev-journal-title><issn pub-type="epub">2562-0959</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v8i1e69796</article-id><article-id pub-id-type="doi">10.2196/69796</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Letter</subject></subj-group></article-categories><title-group><article-title>The Influence of Popular Media on Public Interest in Red-Light Therapy: Longitudinal Trend Analysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Shen</surname><given-names>Catherine Z</given-names></name><degrees>BA</degrees><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Zhao</surname><given-names>Aaron T</given-names></name><degrees>BS</degrees></contrib></contrib-group><aff id="aff1"><institution>Perelman School of Medicine, University of Pennsylvania</institution><addr-line>3400 Civic Center Blvd</addr-line><addr-line>Philadelphia</addr-line><addr-line>PA</addr-line><country>United States</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Dellavalle</surname><given-names>Robert</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Dal</surname><given-names>Emre</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Jiang</surname><given-names>Simon</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Aaron T Zhao, BS, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA, 19104, United States, 1 240-396-6874; <email>aaron.zhao@pennmedicine.upenn.edu</email></corresp></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>12</day><month>6</month><year>2025</year></pub-date><volume>8</volume><elocation-id>e69796</elocation-id><history><date date-type="received"><day>08</day><month>12</month><year>2024</year></date><date date-type="rev-recd"><day>13</day><month>04</month><year>2025</year></date><date date-type="accepted"><day>01</day><month>05</month><year>2025</year></date></history><copyright-statement>&#x00A9; Catherine Z Shen, Aaron T Zhao. Originally published in JMIR Dermatology (<ext-link ext-link-type="uri" xlink:href="http://derma.jmir.org">http://derma.jmir.org</ext-link>), 12.6.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Dermatology, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="http://derma.jmir.org">http://derma.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://derma.jmir.org/2025/1/e69796"/><abstract><sec><title>Abstract</title><p>TikTok&#x2019;s influence has significantly increased public interest in red-light therapy, surpassing that for traditional skin care treatments; this highlights the powerful role of social media in shaping health care trends and underscores the need for health care providers to stay informed about viral social media trends on treatment.</p></sec></abstract><kwd-group><kwd>social media</kwd><kwd>dermatology</kwd><kwd>trends</kwd><kwd>red-light therapy</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>The intersection of social media and health care information dissemination has created new challenges and opportunities for health care professionals. Social media platforms, particularly TikTok, increasingly shape public interest in medical treatments. In early 2024, red-light therapy (RLT) emerged as a viral skin care trend on TikTok; celebrities featured LED masks from brands such as Omnilux in their content. By February 2024, the hashtag &#x201C;Red LED light therapy&#x201D; had &#x003E;70 million views on TikTok, driving interest in home-use devices ranging in price from US $100 to $3500 [<xref ref-type="bibr" rid="ref1">1</xref>]. This attention came despite limited scientific understanding of the long-term effects and safety, especially for home use [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>].</p><p>RLT, also known as photobiomodulation or low-level laser therapy, is purported to have beneficial effects on skin health [<xref ref-type="bibr" rid="ref4">4</xref>]. While some clinical applications of this therapy are well documented, recent interest primarily focuses on consumer-grade devices and home treatments, raising concerns among health care providers about safety and efficacy [<xref ref-type="bibr" rid="ref5">5</xref>]. Here, we examine the impact of TikTok exposure on public interest in RLT and compare trends with conventional skin care treatments.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Overview</title><p>We analyzed Google Trends data from November 2019 to November 2024 for terms related to RLT (&#x201C;light therapy,&#x201D; &#x201C;red therapy,&#x201D; &#x201C;red light masks,&#x201D; &#x201C;red therapy benefits,&#x201D; &#x201C;photobiomodulation,&#x201D; &#x201C;low level laser therapy&#x201D;) and control terms representing traditional skin care treatments (&#x201C;chemical peel,&#x201D; &#x201C;skin care,&#x201D; &#x201C;exfoliation&#x201D;) selected systematically based on preliminary TikTok hashtag analysis and existing literature on light therapy terminology. RLT-related terms were chosen based on their relevance to clinical applications and consumer terminology used on social media. Control terms were related to traditional skin care treatments with comparable market presence to provide appropriate comparison baselines.</p><p>Statistical analyses included trend analysis using linear regression and Mann-Kendall tests, with structural breaks identified using Chow tests. All analyses used Python 3.13.0, with significance set at <italic>P</italic>&#x003C;.05. Artificial intelligence tools helped generate visual representations of search trends over time.</p></sec><sec id="s2-2"><title>Ethical Considerations</title><p>The University of Pennsylvania waived institutional review board approval for this study as it exclusively used deidentified, publicly available data.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><p>All RLT-related terms, except &#x201C;low level laser therapy&#x201D; (<italic>P</italic>=.30), showed significant increases in search volume after February 2024, with the average search volume increasing from 27.8 to 60.5 searches per term (118% increase) compared to baseline (<italic>P</italic>&#x003C;.001). <xref ref-type="fig" rid="figure1">Figure 1</xref> shows the dramatic increase in searches for RLT terms compared to control terms. <xref ref-type="table" rid="table1">Table 1</xref> presents a statistical analysis of key terms.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>Google Trends search interest for red-light therapy versus traditional skin care terms (2023&#x2010;2024), illustrating the substantial increase in search interest for red-light therapy terms compared to traditional skin care terms following viral TikTok exposure in February 2024. Red-light therapy terms included &#x201C;red light masks,&#x201D; &#x201C;light therapy,&#x201D; and &#x201C;red therapy.&#x201D; Control terms included &#x201C;skin care,&#x201D; &#x201C;exfoliation,&#x201D; and &#x201C;chemical peel.&#x201D;</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="derma_v8i1e69796_fig01.png"/></fig><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Analysis of red-light therapy search terms from November 2019 to November 2024.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Search term</td><td align="left" valign="bottom">Linear regression slope</td><td align="left" valign="bottom"><italic>R</italic><sup>2</sup></td><td align="left" valign="bottom">Mann-Kendall &#x03C4;</td><td align="left" valign="bottom">Structural break (<italic>P</italic> value)</td></tr></thead><tbody><tr><td align="left" valign="top">&#x201C;Red light masks&#x201D;</td><td align="left" valign="top">0.08</td><td align="left" valign="top">0.45</td><td align="left" valign="top">0.38</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top">&#x201C;Light therapy&#x201D;</td><td align="left" valign="top">0.09</td><td align="left" valign="top">0.62</td><td align="left" valign="top">0.58</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top">&#x201C;Red therapy&#x201D;</td><td align="left" valign="top">0.15</td><td align="left" valign="top">0.72</td><td align="left" valign="top">0.68</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top">&#x201C;Skin care&#x201D;</td><td align="left" valign="top">&#x2212;0.01</td><td align="left" valign="top">0.03</td><td align="left" valign="top">&#x2212;0.11</td><td align="left" valign="top">&#x2014;<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup></td></tr><tr><td align="left" valign="top">&#x201C;Exfoliation&#x201D;</td><td align="left" valign="top">&#x2212;0.02</td><td align="left" valign="top">0.04</td><td align="left" valign="top">&#x2212;0.14</td><td align="left" valign="top">&#x2014;</td></tr><tr><td align="left" valign="top">&#x201C;Chemical peel&#x201D;</td><td align="left" valign="top">&#x2212;0.008</td><td align="left" valign="top">0.009</td><td align="left" valign="top">&#x2212;0.07</td><td align="left" valign="top">&#x2014;</td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>Not applicable.</p></fn></table-wrap-foot></table-wrap><p>Linear regression revealed significant positive trends for RLT terms (slopes: 0.08&#x2010;0.15; all <italic>P</italic>&#x003C;.001), while control terms showed either no significant trends or slight declines. Mann-Kendall tests confirmed strong upward trends for RLT-related terms (&#x03C4;=0.38&#x2010;0.68; all <italic>P</italic>&#x003C;.001). Structural breaks occurred in early 2024 (all <italic>P</italic>&#x003C;.001), coinciding with TikTok exposure.</p></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><p>Public interest in RLT significantly increased in early 2024 following its viral popularity on TikTok; by February 2024, &#x201C;Red LED light therapy&#x201D; amassed &#x003E;70 million views [<xref ref-type="bibr" rid="ref1">1</xref>]. This surge in interest presents both opportunities and challenges for dermatology practitioners and the broader medical community. The rapid adoption of consumer-grade devices, often supported by inconsistent treatment protocols, raises concerns about patient safety and the need for professional oversight.</p><p>Average search volume for chemical peels, a traditional treatment, slightly decreased (from 25.8 to 25.5, a &#x2212;1.2% change; <italic>P</italic>=.09) despite projected market growth, suggesting a shift in consumer interest toward emerging technologies rather than a true decline in established treatments.</p><p>Although current research supports RLT for targeted conditions such as wound healing, inflammatory acne, and photoaging, social media claims often amplify its benefits beyond available evidence [<xref ref-type="bibr" rid="ref6">6</xref>-<xref ref-type="bibr" rid="ref10">10</xref>]. This underscores the need for additional randomized controlled trials, particularly studies examining the efficacy and safety of consumer devices.</p><p>Health care providers must address patients&#x2019; growing interest in RLT while maintaining high standards of clinical care. This requires developing structured approaches to patient education that address common misconceptions and provide evidence-based guidelines.</p><p>The phenomenon has broader implications for public health trends. Improved regulation of consumer devices, standardized safety guidelines, and enhanced adverse event&#x2013;reporting systems are urgently needed. Public health communication must evolve to address viral trends, particularly those involving medical devices or treatments. Rapid dissemination of medical information on social media presents opportunities and challenges, highlighting the need for responsive professional education and communication strategies.</p><p>Study limitations include the broader scope of RLT keywords (which encompass both dermatologic and other applications) compared to the primarily dermatologic control terms, though the analysis focused specifically on consumer interest rather than clinical equivalence between treatments. Google Trends data also do not reflect actual treatment use or capture detailed demographic data. Future research should incorporate sales data, adverse event reports, and clinical outcomes to comprehensively explore this phenomenon.</p><p>These findings have significant implications for dermatology and patient care. As social media continues to shape health care trends, medical professionals must adapt education approaches while maintaining evidence-based practices. This may require new frameworks for addressing viral health care trends and improved methods for communicating scientific evidence. The rapid rise in RLT interest is a case study in how social media can quickly transform patient interest and treatment expectations, requiring the medical community to respond with agility and scientific rigor.</p></sec></body><back><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">RLT</term><def><p>red-light therapy</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="web"><person-group person-group-type="author"><name name-style="western"><surname>Onque</surname><given-names>R</given-names> </name></person-group><article-title>High-tech red light therapy is trending on TikTok and &#x2018;all skin types can benefit,&#x2019; dermatologist says: here&#x2019;s what to know</article-title><source>CNBC</source><access-date>2025-06-05</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://www.cnbc.com/2024/02/29/red-light-therapy-is-trending-on-tiktok-heres-what-to-know.html">https://www.cnbc.com/2024/02/29/red-light-therapy-is-trending-on-tiktok-heres-what-to-know.html</ext-link></comment></nlm-citation></ref><ref id="ref2"><label>2</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Jagdeo</surname><given-names>J</given-names> </name><name name-style="western"><surname>Nguyen</surname><given-names>JK</given-names> </name><name name-style="western"><surname>Ho</surname><given-names>D</given-names> </name><etal/></person-group><article-title>Safety of light emitting diode-red light on human skin: two randomized controlled trials</article-title><source>J Biophotonics</source><year>2020</year><month>03</month><volume>13</volume><issue>3</issue><fpage>31483941</fpage><pub-id pub-id-type="doi">10.1002/jbio.201960014</pub-id><pub-id pub-id-type="medline">31483941</pub-id></nlm-citation></ref><ref id="ref3"><label>3</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Cohen</surname><given-names>M</given-names> </name><name name-style="western"><surname>Austin</surname><given-names>E</given-names> </name><name name-style="western"><surname>Masub</surname><given-names>N</given-names> </name><name name-style="western"><surname>Kurtti</surname><given-names>A</given-names> </name><name name-style="western"><surname>George</surname><given-names>C</given-names> </name><name name-style="western"><surname>Jagdeo</surname><given-names>J</given-names> </name></person-group><article-title>Home-based devices in dermatology: a systematic review of safety and efficacy</article-title><source>Arch Dermatol Res</source><year>2022</year><month>04</month><volume>314</volume><issue>3</issue><fpage>239</fpage><lpage>246</lpage><pub-id pub-id-type="doi">10.1007/s00403-021-02231-0</pub-id><pub-id pub-id-type="medline">33938981</pub-id></nlm-citation></ref><ref id="ref4"><label>4</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Glass</surname><given-names>GE</given-names> </name></person-group><article-title>Photobiomodulation: the clinical applications of low-level light therapy</article-title><source>Aesthet Surg J</source><year>2021</year><month>05</month><day>18</day><volume>41</volume><issue>6</issue><fpage>723</fpage><lpage>738</lpage><pub-id pub-id-type="doi">10.1093/asj/sjab025</pub-id><pub-id pub-id-type="medline">33471046</pub-id></nlm-citation></ref><ref id="ref5"><label>5</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Mineroff</surname><given-names>J</given-names> </name><name name-style="western"><surname>Maghfour</surname><given-names>J</given-names> </name><name name-style="western"><surname>Ozog</surname><given-names>DM</given-names> </name><name name-style="western"><surname>Lim</surname><given-names>HW</given-names> </name><name name-style="western"><surname>Kohli</surname><given-names>I</given-names> </name><name name-style="western"><surname>Jagdeo</surname><given-names>J</given-names> </name></person-group><article-title>Photobiomodulation CME part II: clinical applications in dermatology</article-title><source>J Am Acad Dermatol</source><year>2024</year><month>11</month><volume>91</volume><issue>5</issue><fpage>805</fpage><lpage>815</lpage><pub-id pub-id-type="doi">10.1016/j.jaad.2023.10.074</pub-id><pub-id pub-id-type="medline">38307144</pub-id></nlm-citation></ref><ref id="ref6"><label>6</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Giannakopoulos</surname><given-names>E</given-names> </name><name name-style="western"><surname>Katopodi</surname><given-names>A</given-names> </name><name name-style="western"><surname>Rallis</surname><given-names>M</given-names> </name><name name-style="western"><surname>Politopoulos</surname><given-names>K</given-names> </name><name name-style="western"><surname>Alexandratou</surname><given-names>E</given-names> </name></person-group><article-title>The effects of low power laser light at 661 nm on wound healing in a scratch assay fibroblast model</article-title><source>Lasers Med Sci</source><year>2022</year><month>12</month><day>27</day><volume>38</volume><issue>1</issue><fpage>27</fpage><pub-id pub-id-type="doi">10.1007/s10103-022-03670-5</pub-id><pub-id pub-id-type="medline">36574084</pub-id></nlm-citation></ref><ref id="ref7"><label>7</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Chaves</surname><given-names>M de A</given-names> </name><name name-style="western"><surname>Ara&#x00FA;jo</surname><given-names>A de</given-names> </name><name name-style="western"><surname>Piancastelli</surname><given-names>ACC</given-names> </name><name name-style="western"><surname>Pinotti</surname><given-names>M</given-names> </name></person-group><article-title>Effects of low-power light therapy on wound healing: LASER x LED</article-title><source>An Bras Dermatol</source><year>2014</year><volume>89</volume><issue>4</issue><fpage>616</fpage><lpage>623</lpage><pub-id pub-id-type="doi">10.1590/abd1806-4841.20142519</pub-id><pub-id pub-id-type="medline">25054749</pub-id></nlm-citation></ref><ref id="ref8"><label>8</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Wu</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Deng</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Huang</surname><given-names>P</given-names> </name></person-group><article-title>Application of red light therapy for moderate-to-severe acne vulgaris: a systematic review and meta-analysis</article-title><source>J Cosmet Dermatol</source><year>2021</year><month>11</month><volume>20</volume><issue>11</issue><fpage>3498</fpage><lpage>3508</lpage><pub-id pub-id-type="doi">10.1111/jocd.14369</pub-id><pub-id pub-id-type="medline">34363730</pub-id></nlm-citation></ref><ref id="ref9"><label>9</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Na</surname><given-names>JI</given-names> </name><name name-style="western"><surname>Suh</surname><given-names>DH</given-names> </name></person-group><article-title>Red light phototherapy alone is effective for acne vulgaris: randomized, single-blinded clinical trial</article-title><source>Dermatol Surg</source><year>2007</year><month>10</month><volume>33</volume><issue>10</issue><fpage>1228</fpage><lpage>1233</lpage><pub-id pub-id-type="doi">10.1111/j.1524-4725.2007.33258.x</pub-id><pub-id pub-id-type="medline">17903156</pub-id></nlm-citation></ref><ref id="ref10"><label>10</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Couturaud</surname><given-names>V</given-names> </name><name name-style="western"><surname>Le Fur</surname><given-names>M</given-names> </name><name name-style="western"><surname>Pelletier</surname><given-names>M</given-names> </name><name name-style="western"><surname>Granotier</surname><given-names>F</given-names> </name></person-group><article-title>Reverse skin aging signs by red light photobiomodulation</article-title><source>Skin Res Technol</source><year>2023</year><month>07</month><volume>29</volume><issue>7</issue><fpage>e13391</fpage><pub-id pub-id-type="doi">10.1111/srt.13391</pub-id><pub-id pub-id-type="medline">37522497</pub-id></nlm-citation></ref></ref-list></back></article>