@Article{info:doi/10.2196/54217,
author="Olsson, Sofia Eva
and Sreepad, Bhavana
and Lee, Trevor
and Fasih, Manal
and Fijany, Arman",
title="Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis",
journal="JMIR Dermatol",
year="2024",
month="Feb",
day="20",
volume="7",
pages="e54217",
keywords="acetyl-hexapeptide-8; anti-aging; anti-wrinkle; Argireline; BoNT; botox; botulinum neurotoxin; cosmetic dermatology; cosmetic; dermatologist; dermatology; injectable neurotoxin; neurotoxin; skin specialist; topical agent; topical",
abstract="Background: Acetyl hexapeptide-8, also known as Argireline, is a topical, short-acting, synthetic peptide that has recently gained popularity for its antiwrinkle effects. This agent has emerged as a more accessible alternative to botulinum neurotoxin. Objective: This study evaluates the public interest in acetyl hexapeptide-8 in the United States from 2013 to 2023, as described by search volume on Google, the most-used search engine. Methods: We analyzed the longitudinal relative monthly search volume from January 1, 2013, to January 1, 2023, for acetyl hexapeptide--related terms. We compared the internet search trends for ``Botox'' during this period to ``Argireline.'' Results: The terms ``Argireline'' and ``Botox in a Bottle'' both had substantial increases in search volume in 2022. Although its search volume is drastically increasing, ``Argireline'' was less searched than ``Botox,'' which had a stable, up-trending search volume over the past decade. Conclusions: The increasing interest in acetyl hexapeptide-8 may be due to its cost-effectiveness and use as a botulinum neurotoxin alternative. Affordability, over-the-counter availability, and ease of self-application of the agent suggest its potential to enhance accessibility to cosmetic dermatologic care. ",
issn="2562-0959",
doi="10.2196/54217",
url="https://derma.jmir.org/2024/1/e54217",
url="https://doi.org/10.2196/54217",
url="http://www.ncbi.nlm.nih.gov/pubmed/38376906"
}