https://derma.jmir.org/issue/feedJMIR Dermatology2023-01-04T09:30:04-05:00JMIR Publicationseditor@jmir.orgOpen Journal Systems This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published JMIR Dermatology, is properly cited. The complete bibliographic information, a link to the original publication on https://derma.jmir.org/, as well as this copyright and license information must be included. JMIR Dermatology is the official journal of the International Society of Digital Health in Dermatology ( ISDHD), formerly the International Society of Teledermatology (ISTD). https://derma.jmir.org/2024/1/e51962/ The Potential of Exercise on Lifestyle and Skin Function: Narrative Review2024-03-14T09:15:25-04:00Ryosuke OizumiYoshie SugimotoHiromi Aibara<strong>Background:</strong> The skin is an important organ of the human body and has moisturizing and barrier functions. Factors such as sunlight and lifestyle significantly affect these skin functions, with sunlight being extremely damaging. The effects of lifestyle habits such as smoking, diet, and sleep have been studied extensively. It has been found that smoking increases the risk of wrinkles, while excessive fat and sugar intake leads to skin aging. Lack of sleep and stress are also dangerous for the skin’s barrier function. In recent years, the impact of exercise habits on skin function has been a focus of study. Regular exercise is associated with increased blood flow to the skin, elevated skin temperature, and improved skin moisture. Furthermore, it has been shown to improve skin structure and rejuvenate its appearance, possibly through promoting mitochondrial biosynthesis and affecting hormone secretion. Further research is needed to understand the effects of different amounts and content of exercise on the skin. <strong>Objective:</strong> This study aims to briefly summarize the relationship between lifestyle and skin function and the mechanisms that have been elucidated so far and introduce the expected effects of exercise on skin function. <strong>Methods:</strong> We conducted a review of the literature using PubMed and Google Scholar repositories for relevant literature published between 2000 and 2022 with the following keywords: exercise, skin, and life habits. <strong>Results:</strong> Exercise augments the total spectrum power density of cutaneous blood perfusion by a factor of approximately 8, and vasodilation demonstrates an enhancement of approximately 1.5-fold. Regular exercise can also mitigate age-related skin changes by promoting mitochondrial biosynthesis. However, not all exercise impacts are positive; for instance, swimming in chlorinated pools may harm the skin barrier function. Hence, the exercise environment should be considered for its potential effects on the skin. <strong>Conclusions:</strong> This review demonstrates that exercise can potentially enhance skin function retention. 2024-03-14T09:15:25-04:00 https://derma.jmir.org/2024/1/e55508/ Assessing the Utility of Multimodal Large Language Models (GPT-4 Vision and Large Language and Vision Assistant) in Identifying Melanoma Across Different Skin Tones2024-03-13T09:15:20-04:00Katrina CironeMohamed AkroutLatif AbidAmanda OakleyThe large language models GPT-4 Vision and Large Language and Vision Assistant are capable of understanding and accurately differentiating between benign lesions and melanoma, indicating potential incorporation into dermatologic care, medical research, and education.2024-03-13T09:15:20-04:00 https://derma.jmir.org/2024/1/e50431/ Does Male Skin Care Content on Instagram Neglect Skin Cancer Prevention?2024-03-13T09:15:04-04:00Alexa CarboniOlnita MartiniJessica KirkNathaniel A MarroquinCorinne RicciMelissa ChengMindy D SzetoKayd J PulsipherRobert P DellavalleThis research letter assesses male skin care content on social media in order to bring to light the lack of content regarding skin cancer prevention posted on Instagram for male audiences.2024-03-13T09:15:04-04:00 https://derma.jmir.org/2024/1/e49965/ Oral Cannabidiol for Seborrheic Dermatitis in Patients With Parkinson Disease: Randomized Clinical Trial2024-03-11T09:45:04-04:00Isaac WeberCaterina Zagona-PrizioTorunn E SivesindMadeline AdelmanMindy D SzetoYing LiuStefan H SillauJacquelyn BainbridgeJost KlawitterCristina SempioCory A DunnickMaureen A LeeheyRobert P Dellavalle<strong>Background:</strong> Seborrheic dermatitis (SD) affects 18.6%-59% of persons with Parkinson disease (PD), and recent studies provide evidence that oral cannabidiol (CBD) therapy could reduce sebum production in addition to improving motor and psychiatric symptoms in PD. Therefore, oral CBD could be useful for improving symptoms of both commonly co-occurring conditions. <strong>Objective:</strong> This study investigates whether oral CBD therapy is associated with a decrease in SD severity in PD. <strong>Methods:</strong> Facial photographs were collected as a component of a randomized (1:1 CBD vs placebo), parallel, double-blind, placebo-controlled trial assessing the efficacy of a short-term 2.5 mg per kg per day oral sesame solution CBD-rich cannabis extract (formulated to 100 mg/mL CBD and 3.3 mg/mL THC) for reducing motor symptoms in PD. Participants took 1.25 mg per kg per day each morning for 4 ±1 days and then twice daily for 10 ±4 days. Reviewers analyzed the photographs independently and provided a severity ranking based on the Seborrheic Dermatitis Area and Severity Index (SEDASI) scale. Baseline demographic and disease characteristics, as well as posttreatment SEDASI averages and the presence of SD, were analyzed with 2-tailed <i>t</i> tests and Pearson <i>χ</i><sup>2</sup> tests. SEDASI was analyzed with longitudinal regression, and SD was analyzed with generalized estimating equations. <strong>Results:</strong> A total of 27 participants received a placebo and 26 received CBD for 16 days. SD severity was low in both groups at baseline, and there was no treatment effect. The risk ratio for patients receiving CBD, post versus pre, was 0.69 (95% CI 0.41-1.18; <i>P</i>=.15), compared to 1.20 (95% CI 0.88-1.65; <i>P</i>=.26) for the patients receiving the placebo. The within-group pre-post change was not statistically significant for either group, but they differed from each other (<i>P</i>=.07) because there was an estimated improvement for the CBD group and an estimated worsening for the placebo group. <strong>Conclusions:</strong> This study does not provide solid evidence that oral CBD therapy reduces the presence of SD among patients with PD. While this study was sufficiently powered to detect the primary outcome (efficacy of CBD on PD motor symptoms), it was underpowered for the secondary outcomes of detecting changes in the presence and severity of SD. Multiple mechanisms exist through which CBD can exert beneficial effects on SD pathogenesis. Larger studies, including participants with increased disease severity and longer treatment periods, may better elucidate treatment effects and are needed to determine CBD’s true efficacy for affecting SD severity. <strong>Trial Registration:</strong> ClinicalTrials.gov NCT03582137; https://clinicaltrials.gov/ct2/show/NCT03582137 2024-03-11T09:45:04-04:00 https://derma.jmir.org/2024/1/e41657/ From the Cochrane Library: Visual Inspection and Dermoscopy, Alone or in Combination, for Diagnosing Keratinocyte Skin Cancers in Adults2024-03-07T09:45:04-05:00Colleen M KleinTorunn E SivesindRobert P Dellavalle2024-03-07T09:45:04-05:00 https://derma.jmir.org/2024/1/e50163/ Readability and Health Literacy Scores for ChatGPT-Generated Dermatology Public Education Materials: Cross-Sectional Analysis of Sunscreen and Melanoma Questions2024-03-06T09:15:18-05:00Katie RosterRebecca B KannBanu FarabiChristian GronbeckNicholas BrownstoneShari R Lipner2024-03-06T09:15:18-05:00 https://derma.jmir.org/2024/1/e48451/ Potential Use of ChatGPT in Responding to Patient Questions and Creating Patient Resources2024-03-06T09:15:03-05:00Kelly ReynoldsTrilokraj TejasviChatGPT (OpenAI) is an artificial intelligence–based free natural language processing model that generates complex responses to user-generated prompts. The advent of this tool comes at a time when physician burnout is at an all-time high, which is attributed at least in part to time spent outside of the patient encounter within the electronic medical record (documenting the encounter, responding to patient messages, etc). Although ChatGPT is not specifically designed to provide medical information, it can generate preliminary responses to patients’ questions about their medical conditions and can precipitately create educational patient resources, which do inevitably require rigorous editing and fact-checking on the part of the health care provider to ensure accuracy. In this way, this assistive technology has the potential to not only enhance a physician’s efficiency and work-life balance but also enrich the patient-physician relationship and ultimately improve patient outcomes.2024-03-06T09:15:03-05:00 https://derma.jmir.org/2024/1/e54052/ A Content Analysis of Indoor Tanning Twitter Chatter During COVID-19 Shutdowns: Cross-Sectional Qualitative Study2024-03-04T09:15:03-05:00Laurie GroshonMolly E WaringAaron J BlashillKristen DeanSanaya BankwallaLindsay PalmerSherry PagotoBackground: Indoor tanning is a preventable risk factor for skin cancer. Statewide shutdowns during the COVID-19 pandemic resulted in temporary closures of tanning businesses. Little is known about how tanners reacted to losing access to tanning businesses. Objective: This study aimed to analyze Twitter (subsequently rebranded as X) chatter about indoor tanning during the statewide pandemic shutdowns. Methods: We collected tweets from March 15 to April 30, 2020, and performed a directed content analysis of a random sample of 20% (1165/5811) of tweets from each week. The 2 coders independently rated themes (κ=0.67-1.0; 94%-100% agreement). Results: About half (589/1165, 50.6%) of tweets were by people unlikely to indoor tan, and most of these mocked tanners or the act of tanning (562/589, 94.9%). A total of 34% (402/1165) of tweets were posted by users likely to indoor tan, and most of these (260/402, 64.7%) mentioned missing tanning beds, often citing appearance- or mood-related reasons or withdrawal. Some tweets by tanners expressed a desire to purchase or use home tanning beds (90/402, 22%), while only 3.9% (16/402) mentioned tanning alternatives (eg, self-tanner). Very few tweets (29/1165, 2.5%) were public health messages about the dangers of indoor tanning. Conclusions: Findings revealed that during statewide shutdowns, half of the tweets about indoor tanning were mocking tanning bed users and the tanned look, while about one-third were indoor tanners reacting to their inability to access tanning beds. Future work is needed to understand emerging trends in tanning post pandemic. 2024-03-04T09:15:03-05:00 https://derma.jmir.org/2024/1/e40053/ The Value of Teledermatology Advice for Skin Toxicity in Oncology: Experience From a Pilot Study2024-02-29T12:30:04-05:00Sofie MylleJorien PapeleuIsabelle HoorensEvelien VerhaegheLieve Brochez2024-02-29T12:30:04-05:00 https://derma.jmir.org/2024/1/e49954/ Atrophic Postacne Scar Treatment: Narrative Review2024-02-21T09:15:03-05:00Enas AttiaAcne scarring is a frequent complication of acne. Scars negatively impact psychosocial and physical well‐being. Optimal treatments significantly improve the appearance, quality of life, and self-esteem of people with scarring. A wide range of interventions have been proposed for acne scars. This narrative review aimed to focus on facial atrophic scarring interventions. The management of acne scarring includes various types of resurfacing (chemical peels, lasers, and dermabrasion); the use of injectable fillers; and surgical methods, such as needling, punch excision, punch elevation, or subcision. Since the scarred tissue has impaired regeneration abilities, the future implementation of stem or progenitor regenerative medical techniques is likely to add considerable value. There are limited randomized controlled trials that aimed to determine which treatment options should be considered the gold standard. Combining interventions would likely produce more benefit compared to the implementation of a single method.2024-02-21T09:15:03-05:00