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GLP-1 is released by L cells in the intestine, and research in rats suggested that leptin potently stimulated postprandial GLP-1 release via leptin receptors on intestinal L cells [31,32]. Thus, our model posits that lower leptin level is associated with blunted postprandial GLP-1 response. Supporting this prediction, individuals with higher leptin levels have demonstrated more robust GLP-1 responses to food intake [33].
JMIR Res Protoc 2025;14:e66554
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