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Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

GLP-1 is released by L cells in the intestine, and research in rats suggested that leptin potently stimulated postprandial GLP-1 release via leptin receptors on intestinal L cells [31,32]. Thus, our model posits that lower leptin level is associated with blunted postprandial GLP-1 response. Supporting this prediction, individuals with higher leptin levels have demonstrated more robust GLP-1 responses to food intake [33].

Pamela K Keel, Lindsay P Bodell, Sarrah I Ali, Austin Starkey, Jenna Trotta, J Woody Luxama, Chloé Halfhide, Naomi G Hill, Jonathan Appelbaum, Diana L Williams

JMIR Res Protoc 2025;14:e66554