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Lichen Planus Pigmentosus and Vitiligo in a 61-Year-Old Filipino Man: Case Report
The autoimmune hypothesis has also been implicated in LPP. Abnormal T-lymphocyte function and the presence of immunoreactants, like fibrinogen and C3 and immunoglobulin M in colloid bodies, have been identified at the basement membrane zone [4].
The coexistence of LPP with vitiligo has not been well studied. However, the autoimmune hypothesis has also been identified as a probable cause for vitiligo.
JMIR Dermatol 2024;7:e50401
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Because ICBs have the potential to cause severe immune-related adverse events or exacerbate underlying autoimmune conditions, patients with cancer and a preexisting autoimmune disease who undergo treatment with ICBs need balanced information about ICBs [8-10]. Results from our prior learning needs assessment in this population suggest that some patients like to learn on their own to allow time to digest information and ask questions later [11].
JMIR Cancer 2024;10:e53443
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Exploring the Perspectives of Patients Living With Lupus: Retrospective Social Listening Study
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease affecting multiple systems in the body; it is characterized by fluctuating symptoms and periods of exacerbation and remission [1-3]. The most common symptoms of SLE include fatigue, skin rashes, fever, and joint pain or swelling [3]. SLE has several phenotypes and clinical manifestations involving various organs, including the joints, skin, kidneys, and organs of the neurological or hematological systems [1,2].
JMIR Form Res 2024;8:e52768
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Multiple sclerosis (MS) is considered to be an autoimmune disease triggered by environmental factors that act on a genetically susceptible host. Both major histocompatibility complex (MHC) and non-MHC genes are risk factors for the development of MS. In addition, environmental factors such as low vitamin D, low ultraviolet radiation exposure, cigarette smoking, obesity, and Epstein-Barr virus exposure can increase the risk for both the development of MS and a more severe disease course.
JMIR Res Protoc 2024;13:e46709
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The origin of autoimmune disease is a disruption of immune tolerance of self-antigens thought to occur in genetically susceptible individuals after exposure to environmental triggers. Possible environmental factors that predispose to autoimmunity include exposure to infectious agents, ultraviolet light, dietary components, chemicals, xenobiotics, toxins, and stress, as well as reduced exposure to factors that protect from the development of autoimmune diseases.
JMIR Res Protoc 2023;12:e48387
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Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease. It is characterized by a broad spectrum of manifestations, depending on the affected organs (eg, skin, kidney, lung, heart, brain, etc), the chronicity of the disease, and the severity of disease activity at the time of presentation [1]. According to a recent review of several registries in the United States, the reported prevalence of SLE ranges from 43 to 200 people per 100,000 people, depending on ethnicity [2].
J Med Internet Res 2023;25:e44660
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Acute Spontaneous Colonic Perforation in a Case of Newly Confirmed Scleroderma: Case Report
Scleroderma, sometimes more colloquially known as systemic sclerosis, is a group of autoimmune diseases that principally affects the skin, blood vessels, muscles, and viscera [1]. One of the more well-known subgroups of scleroderma is the limited cutaneous form of the multisystem connective tissue disorder known as CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasis) syndrome [2].
Interact J Med Res 2023;12:e43295
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The inclusion of biological factors in understanding fatigue supports the idea that even when mood disorders are absent (common associations of fatigue), fatigue still exists in autoimmune and inflammatory diseases, including SLE [32].
The culture, value, belief, and lifeway factors influencing SLE-related fatigue were the Qo L and individual functioning, whereas in terms of kinship and social factors, stress and social support should be taken into consideration.
Asian Pac Isl Nurs J 2022;6(1):e39132
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Common Dermatologic Disorders in Down Syndrome: Systematic Review
The study found no concomitant vitiligo or autoimmune disease, as well as no first-degree relatives with AA [59]. By contrast, Ramot et al [60] reported that 8 (57%) of patients had a 1st or 2nd degree relative with AA. Ramot et al [60] and Schepis et al [61] reported 6 (42.9%) and 4 (33.3%) with thyroid abnormalities, and 1 (7.1%) and 4 (33.3%) with celiac disease.
JMIR Dermatol 2022;5(1):e33391
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