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Cyclosporine in the Treatment of Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome: Retrospective Cohort Study

Cyclosporine in the Treatment of Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome: Retrospective Cohort Study

Cyclosporine was the preferred treatment due to concern for prolonged prednisone taper, to avoid extended immunosuppression in the setting of recent or concurrent infection, to restart immunologic treatment of metastatic melanoma, for more rapid improvement of symptoms, and due to previous successful treatment of DRESS syndrome with cyclosporine. Of the 19 cases in this case series, 17 patients had a resolution of DRESS syndrome (17/19, 89%) with treatment of cyclosporine.

Sophia Zita, Lindsey Broussard, Jeremy Hugh, Sabrina Newman

JMIR Dermatol 2023;6:e41391