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Comparison of Efficiency of Closed Kinetic Chain Exercises Versus Proprioceptive Exercises in Improving Balance and Gait in People With Hemophilia: Protocol for a Randomized Controlled Trial

Comparison of Efficiency of Closed Kinetic Chain Exercises Versus Proprioceptive Exercises in Improving Balance and Gait in People With Hemophilia: Protocol for a Randomized Controlled Trial

Group 1 is the closed kinetic exercise group, group 2 is the proprioceptive exercise group, and group 3 is the control group. Participants in group 1 and group 2 will receive exercise training twice a week for 12 weeks for a total of 24 sessions of 45 minutes each. The control group will not receive any intervention. Exercise training will continue under the supervision of the physiotherapist. Patients will have completed their factor replacement on the day of exercise.

Tugce Poyraz Isleyen, Ela Tarakci, Gokce Leblebici, Ipek Yeldan, Bulent Zulfikar

JMIR Res Protoc 2025;14:e66770

Interventions to Reduce Serum Per- and Poly-Fluoroalkyl Substances Levels, Improve Cardiovascular Risk Profiles, and Improve Epigenetic Age Acceleration in US Firefighters: Protocol for Randomized Controlled Trial

Interventions to Reduce Serum Per- and Poly-Fluoroalkyl Substances Levels, Improve Cardiovascular Risk Profiles, and Improve Epigenetic Age Acceleration in US Firefighters: Protocol for Randomized Controlled Trial

We also included a smaller intervention group of participants with PFOS Participants randomized into the zone 2 physical activity arm complete a Cardiopulmonary Exercise Test (CPET) before starting their intervention. The CPET uses a mouthpiece and external sensors to measure the heart rate and other cardiovascular health indicators of the individual while they engage in mild exercise on a stationary bicycle.

Reagan Conner, Cynthia Porter, Karen Lutrick, Shawn C Beitel, James Hollister, Olivia Healy, Krystal J Kern, Floris Wardenaar, John J Gulotta, Kepra Jack, Matthew Huentelman, Jefferey L Burgess, Melissa Furlong

JMIR Res Protoc 2025;14:e67120

Older Adults’ Perspectives on Participating in a Synchronous Online Exercise Program: Qualitative Study

Older Adults’ Perspectives on Participating in a Synchronous Online Exercise Program: Qualitative Study

Descriptive characteristics for the ACTIVE, control group (CON), and no-interview participants (N=32). a ACTIVE: exercise group. b CON: waitlist control group. Our thematic analysis identified 3 main themes with respect to participants’ perceptions of exercise in general and with the synchronous online exercise program: health, exercise, and aging beliefs; the pandemic interruption and impacts; and synchronous online exercise programs attenuate barriers to exercise (Textbox 1).

Giulia Coletta, Kenneth S Noguchi, Kayla Beaudoin, Angelica McQuarrie, Ada Tang, Rebecca Ganann, Stuart M Phillips, Meridith Griffin

JMIR Aging 2025;8:e66473

Assessment of Pelvic Motion During Single-Leg Weight-Bearing Tasks Using Smartphone Sensors: Validity Study

Assessment of Pelvic Motion During Single-Leg Weight-Bearing Tasks Using Smartphone Sensors: Validity Study

Specifically, we assessed whether smartphone sensors provide valid estimates of pelvic orientation in the frontal, sagittal, and transverse planes; pelvic mediolateral acceleration; and exercise duration. We further investigated whether smartphone sensors can objectively characterize pelvic motion differences between different single-leg weight-bearing tasks.

Yu Xi, Zhongsheng Li, Surendran Vatatheeswaran, Valter Devecchi, Alessio Gallina

JMIR Rehabil Assist Technol 2025;12:e65342

Personalized mHealth Intervention (StepAdd) for Increasing Physical Activity in Japanese Patients With Type 2 Diabetes: Secondary Analysis of Social Cognitive Theory Measurements of a Single-Arm Pilot Study

Personalized mHealth Intervention (StepAdd) for Increasing Physical Activity in Japanese Patients With Type 2 Diabetes: Secondary Analysis of Social Cognitive Theory Measurements of a Single-Arm Pilot Study

The ρ of 0.355 between change in SR and change in steps supports the centrality of SR in the changes to exercise behavior [3]. Correlations of social cognitive theory constructs at week 12 of the Step Add intervention for Japanese patients with type 2 diabetes. a SI: strategy implementation. b GC: goal completion. c SE-B: self-efficacy for barriers. d SE-T: self-efficacy for task-specific behavior. e SR: self-regulation. f Not applicable.

Kayo Waki, Syunpei Enomoto, Toshimasa Yamauchi, Masaomi Nangaku, Kazuhiko Ohe

JMIR Form Res 2025;9:e60221

User Experience With a Personalized mHealth Service for Physical Activity Promotion in University Students: Mixed Methods Study

User Experience With a Personalized mHealth Service for Physical Activity Promotion in University Students: Mixed Methods Study

After an introduction and onboarding, they received a task sheet with 6 tasks to independently test the service for approximately 30 minutes (eg, finding exercise information, Multimedia Appendix 3). They accessed the prototype via a device (eg, laptop or tablet). After completing each task, participants provided initial feedback on the task sheet and then completed the online questionnaire.

Silke Wittmar, Tom Frankenstein, Vincent Timm, Peter Frei, Nicolas Kurpiers, Stefan Wölwer, Axel Georg Meender Schäfer

JMIR Form Res 2025;9:e64384

Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Accordingly, therapeutic exercise is the mainstay of physiotherapy for knee osteoarthritis as it is an effective and well-tolerated treatment [14]. Exercise intervention in knee osteoarthritis alleviates pain, improves physical performance, and optimizes social, domestic, occupational, and recreational participation [17].

Chidozie E Mbada, Henry Akintunji Awosika, Oluwatobi Ademola Sonuga, Micheal Akande, Tadesse Gebrye, Richard Woolf, Francis Fatoye

J Med Internet Res 2025;27:e58393

Efficacy of a Supervised Exercise Program on Pain, Physical Function, and Quality of Life in Patients With Breast Cancer: Protocol for a Randomized Clinical Trial

Efficacy of a Supervised Exercise Program on Pain, Physical Function, and Quality of Life in Patients With Breast Cancer: Protocol for a Randomized Clinical Trial

Various treatments are currently being studied to alleviate these side effects, including therapeutic exercise. Exercise provides short- and long-term benefits to reduce the symptoms that may appear during treatment in each patient. Here, therapeutic exercise specialists play an important role in helping patients overcome their fear and improve their physical abilities [23]. The American College of Sports Medicine says exercise is associated with improved survival after developing cancer [24].

Jennifer García-Molina, Olalla Saiz-Vázquez, Montserrat Santamaría-Vázquez, Juan Hilario Ortiz-Huerta

JMIR Res Protoc 2025;14:e63891

Generative AI–Enabled Therapy Support Tool for Improved Clinical Outcomes and Patient Engagement in Group Therapy: Real-World Observational Study

Generative AI–Enabled Therapy Support Tool for Improved Clinical Outcomes and Patient Engagement in Group Therapy: Real-World Observational Study

Correlations between completed therapeutic materials, exercise assignments, and treatment engagement (A-C) and treatment success measures (D-F). First, we compared the reliable improvement rate between the groups. Reliable improvement is defined as a significant change in patients’ symptom scores from the beginning to the end of treatment (reduction of ≥6 points in the PHQ-9 or ≥4 points in the GAD-7 total scores). This measure is considered to reflect meaningful clinical progress.

Johanna Habicht, Larisa-Maria Dina, Jessica McFadyen, Mona Stylianou, Ross Harper, Tobias U Hauser, Max Rollwage

J Med Internet Res 2025;27:e60435