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Large-Scale Evaluation and Liver Disease Risk Prediction in Finland’s National Electronic Health Record System: Feasibility Study Using Real-World Data

Large-Scale Evaluation and Liver Disease Risk Prediction in Finland’s National Electronic Health Record System: Feasibility Study Using Real-World Data

The burden of liver disease increases yearly in Finland because the Finnish population age average grows, and obesity and overweight are more common problems in the Finnish population [1]. On average, there are 1000 deaths caused by alcoholic liver disease every year [2]. For the early detection of individuals from the general population at high risk for future severe liver disease, the CLiv D (Chronic Liver Disease score) score was developed.

Viljami Männikkö, Janne Tommola, Emmi Tikkanen, Olli-Pekka Hätinen, Fredrik Åberg

JMIR Med Inform 2025;13:e62978

Impact of Digital Engagement on Weight Loss Outcomes in Obesity Management Among Individuals Using GLP-1 and Dual GLP-1/GIP Receptor Agonist Therapy: Retrospective Cohort Service Evaluation Study

Impact of Digital Engagement on Weight Loss Outcomes in Obesity Management Among Individuals Using GLP-1 and Dual GLP-1/GIP Receptor Agonist Therapy: Retrospective Cohort Service Evaluation Study

The global obesity epidemic continues to pose a significant challenge to public health systems worldwide [1]. Obesity is characterized by excessive fat accumulation that impairs health and is associated with an increased risk of multiple noncommunicable diseases, including type 2 diabetes (T2 D), cardiovascular diseases, and certain cancers [2].

Hans Johnson, David Huang, Vivian Liu, Mahmoud Al Ammouri, Christopher Jacobs, Austen El-Osta

J Med Internet Res 2025;27:e69466

Interactive Effects of Weight Recording Frequency and the Volume of Chat Communication With Health Care Professionals on Weight Loss in mHealth Interventions for Noncommunicable Diseases: Retrospective Observational Study

Interactive Effects of Weight Recording Frequency and the Volume of Chat Communication With Health Care Professionals on Weight Loss in mHealth Interventions for Noncommunicable Diseases: Retrospective Observational Study

Obesity is a major public health challenge and a well-established risk factor for noncommunicable diseases (NCDs), such as hypertension, diabetes, and dyslipidemia. Effective weight management is crucial not only for obesity prevention but also for reducing the risk of NCD-related complications. Obesity is recognized as one of the contributing factors to the onset of NCDs, such as ischemic heart disease, cerebrovascular disease, hypertension, and diabetes mellitus.

Yuta Hagiwara, Takuji Adachi, Masashi Kanai, Kotoe Shimizu, Shinpei Ishida, Takahiro Miki

Interact J Med Res 2025;14:e65863

Glucagon-Like Peptide-1 Receptor Agonists Combined With Personalized Digital Health Care for the Treatment of Metabolic Syndrome in Adults With Obesity: Retrospective Observational Study

Glucagon-Like Peptide-1 Receptor Agonists Combined With Personalized Digital Health Care for the Treatment of Metabolic Syndrome in Adults With Obesity: Retrospective Observational Study

Obesity serves as a primary contributing factor to the development and progression of Met S. Excess adipose tissue, particularly visceral fat, contributes to chronic low-grade inflammation and the release of adipokines, cytokines, and free fatty acids, all of which play vital roles in insulin resistance and metabolic dysregulation [6].

Hala Zakaria, Hadoun Jabri, Sheikha Alshehhi, Milena Caccelli, Joelle Debs, Yousef Said, Joudy Kattan, Noah Almarzooqi, Ali Hashemi, Ihsan Almarzooqi

Interact J Med Res 2025;14:e63079

Digital Health Literacy and Attitudes Toward eHealth Technologies Among Patients With Cardiovascular Disease and Their Implications for Secondary Prevention: Survey Study

Digital Health Literacy and Attitudes Toward eHealth Technologies Among Patients With Cardiovascular Disease and Their Implications for Secondary Prevention: Survey Study

Following guideline recommendations, secondary prevention aims to address modifiable risk factors such as hyperlipidemia, nicotine consumption, arterial hypertension, diabetes mellitus, obesity, chronic stress, and lack of physical activity [3]. Despite the preventive potential of lifestyle modifications supported by guidelines, their implementation remains inadequate.

Greta Ullrich, Alexander Bäuerle, Hannah Vogt, Amir Abbas Mahabadi, Katrin Paldán, Daniel Messiha, Lisa Maria Jahre, Christos Rammos, Tienush Rassaf, Julia Lortz

JMIR Form Res 2025;9:e63057

Evaluation of a Smartphone-Based Weight Loss Intervention with Telephone Support for Merchant Women With Obesity in Côte d'Ivoire: Protocol for a Randomized Controlled Trial

Evaluation of a Smartphone-Based Weight Loss Intervention with Telephone Support for Merchant Women With Obesity in Côte d'Ivoire: Protocol for a Randomized Controlled Trial

Obesity caused an estimated 5 million deaths associated with noncommunicable diseases (NCDs) such as cardiovascular diseases, diabetes, cancers, and chronic respiratory diseases [1]. Additionally, its high prevalence in people 18 years and older is a critical issue, at 17.9% for women and 13.6% for men in 2022. In Africa, the obesity rate was 17% in women and 6.8% in men in 2022 [2]. This difference is particularly significant, making obesity among women an urgent issue.

Rui Usui, Maki Aomori, Shogo Kanamori, Setsuko Watabe, Bi Tra Jamal Sehi, Kei Kawano, Yuka Kanoya

JMIR Res Protoc 2025;14:e69264

Acceptability and Preliminary Efficacy of a Novel Web-Based Physical Activity for the Heart (PATH) Intervention Designed to Promote Physical Activity in Adults With Obesity: Protocol for a Pilot Randomized Controlled Trial

Acceptability and Preliminary Efficacy of a Novel Web-Based Physical Activity for the Heart (PATH) Intervention Designed to Promote Physical Activity in Adults With Obesity: Protocol for a Pilot Randomized Controlled Trial

Only about 14% of adults with obesity attain the minimum levels of physical activity (PA) recommended by public health guidelines to achieve health benefits [1-3].Low levels of PA contribute to the high population burden of cardiovascular disease (CVD) as they increase the relative risk of stroke, coronary heart disease, and diabetes by 60%, 45%, and 30%, respectively [4-6]. Even in the absence of weight loss, regular PA can significantly reduce the risk of CVD among individuals with obesity [3,7,8].

Jacob Kariuki, Lora Burke, Kirk Erickson, Susan Sereika, Sudeshna Paul, Jessica Cheng, Heran Biza, Amjad Abdirahman, Katherine Wilbraham, Heather Milton, Cornelius Brown, Matthew Sells, Foster Osei Baah, Jessica Wells, Rasheeta Chandler, Bethany Barone Gibbs

JMIR Res Protoc 2025;14:e67972

Healthy Mom Zone Adaptive Intervention With a Novel Control System and Digital Platform to Manage Gestational Weight Gain in Pregnant Women With Overweight or Obesity: Study Design and Protocol for a Randomized Controlled Trial

Healthy Mom Zone Adaptive Intervention With a Novel Control System and Digital Platform to Manage Gestational Weight Gain in Pregnant Women With Overweight or Obesity: Study Design and Protocol for a Randomized Controlled Trial

High BMI and GWG may also “program” the child’s metabolism for life [7,8] and increase the future risks for obesity and type 2 diabetes in both mothers and their offspring [1-6]. As such, managing GWG has high clinical and public health significance, and it can improve maternal health and impact the etiology of obesity or diabetes in offspring at a crucial time in the life cycle [1-6,8].

Danielle Symons Downs, Abigail M Pauley, Daniel E Rivera, Jennifer S Savage, Amy M Moore, Danying Shao, Sy-Miin Chow, Constantino Lagoa, Jaimey M Pauli, Owais Khan, Allen Kunselman

JMIR Res Protoc 2025;14:e66637

Coach-Assisted eHealth With Group or Individual Support for Employees With Obesity: Randomized Controlled Trial on Weight, Body Composition, and Health Metrics

Coach-Assisted eHealth With Group or Individual Support for Employees With Obesity: Randomized Controlled Trial on Weight, Body Composition, and Health Metrics

The prevalence of obesity has more than doubled worldwide since the 1970s [1]. Obesity increases the risk for several metabolic, mechanical, and psychiatric conditions, attributing to 8% of deaths worldwide [2,3]. Weight loss is seen to effectively alleviate obesity-related comorbidities, and even a modest 5%-10% weight loss is seen to, for example, lower hypertension and total cholesterol, and prevent the onset of diabetes [4-6].

Siniriikka A Männistö, Kirsi H Pietiläinen, Joona Muotka, Laura-Unnukka Suojanen, Raimo Lappalainen, Riitta Korpela

J Med Internet Res 2025;27:e60436

Impact of In-Person and Mobile Exercise Coaching on Psychosocial Factors Affecting Exercise Adherence in Inactive Women With Obesity: 20-Week Randomized Controlled Trial

Impact of In-Person and Mobile Exercise Coaching on Psychosocial Factors Affecting Exercise Adherence in Inactive Women With Obesity: 20-Week Randomized Controlled Trial

Obesity (BMI ≥30 kg/m2) is a major global health challenge, significantly economically burdening the health care and welfare systems [1,2]. Worldwide, the obesity rate has nearly tripled in the past 35 years, and it is estimated that 1 billion adults will have obesity in 2030 [3-5]. It affects women more than men, with 1 in 5 women and 1 in 7 men living with obesity [5,6]. Obesity increases the risk of noncommunicable diseases, such as cardiovascular disease, metabolic disease, and type 2 diabetes [7-11].

Christina Gjestvang, John Magne Kalhovde, Elene Mauseth Tangen, Hege Clemm, Lene Annette Hagen Haakstad

J Med Internet Res 2025;27:e68462