This paper is in the following e-collection/theme issue:

Reviews in Dermatology (41) Theme Issue: World Skin Health Day (Guinea) (6) Dermatology Health Services Research (63) Health Services Research (557)

Published on in Vol 7 (2024)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/50403, first published .
Hyaluronidase for Dermal Filler Complications: Review of Applications and Dosage Recommendations

Hyaluronidase for Dermal Filler Complications: Review of Applications and Dosage Recommendations

Hyaluronidase for Dermal Filler Complications: Review of Applications and Dosage Recommendations

Authors of this article:

George Kroumpouzos1, 2 Author Orcid Image ;   Patrick Treacy3 Author Orcid Image
Article Authors Cited by (44) Tweetations (3) Metrics Author Video

Journals

  1. Lee J, Lee S, Cho H. The pinhole method as a novel approach to remove residual hyaluronidase powder: a case report. Medical Lasers 2024;13(1):66 View
  2. Nicola A, Pricop M, Ramos-Medina B. Clinical Management With High-Frequency Ultrasound of Recurrent Submental Abscess Formation After Filler Placement: Bacterial Contamination or Immune-Mediated Adverse Event?. Cureus 2024 View
  3. Gonzalez C, Duque-Clavijo V, Kroumpouzos G, Garcia Concha A, Olmos Perez M. Ultrasonographic features of nonvascular complications of hyaluronic acid fillers: a retrospective study at a reference center for dermatologic ultrasonography. Clinics in Dermatology 2024;42(5):538 View
  4. Peros I, Haneke E. Fibrotic reaction to hyaluronic acid fillers in the face. Journal of Cosmetic Dermatology 2024;23(8):2543 View
  5. Baranska-Rybak W, Lajo-Plaza J, Walker L, Alizadeh N. Late-Onset Reactions after Hyaluronic Acid Dermal Fillers: A Consensus Recommendation on Etiology, Prevention and Management. Dermatology and Therapy 2024;14(7):1767 View
  6. Silikovich F, Kroumpouzos G. Nonsurgical Rhinoplasty: Results from a Retrospective Study of Rino-4-Puntos Technique with Hyaluronic Acid. Aesthetic Plastic Surgery 2025;49(3):672 View
  7. Landau M, Klein J, Leizgold F, Kroumpouzos G. Rare and novel complications of botulinum neurotoxin type A and dermal filler injections. Clinics in Dermatology 2024;42(6):701 View
  8. Zhao J, Chen J, Li C, Xiang H, Miao X. Hyaluronidase overcomes the extracellular matrix barrier to enhance local drug delivery. European Journal of Pharmaceutics and Biopharmaceutics 2024;203:114474 View
  9. Eshraghi B, Babaei L, Aghajani M, Aghajani A. Late-onset periorbital edema in patients with a history of facial hyaluronic acid injection: A review on diagnosis and management. Journal of Plastic, Reconstructive & Aesthetic Surgery 2024;99:271 View
  10. Ruiz N, Lopez R, Marques R, Fontenete S. The Redefinition and Volumization of the Lip Area with Hyaluronic Acid: A Case Series. Journal of Clinical Medicine 2024;13(19):5705 View
  11. Coppini M, Caponio V, Mauceri R, Pizzo G, Mauceri N, Lo Muzio L, Campisi G. Aesthetic lip filler augmentation is not free of adverse reactions: lack of evidence-based practice from a systematic review. Frontiers in Oral Health 2024;5 View
  12. Zheng Y, Sha Z, Zhang B. Mentum, Mouth Floor, and Tongue Necrosis Following Hyaluronic Acid Injection for Chin Augmentation. Journal of Craniofacial Surgery 2025;36(1):e89 View
  13. Torabi S, Massry G, Azizzadeh B. Are Tear Trough Fillers Really that Bad?. Facial Plastic Surgery & Aesthetic Medicine 2025;27(1):1 View
  14. Nishimura M, Sakamoto S, Hoshino M, Miyazaki Y, Yamamoto J, Sakashita H, Kusama K, Kikuchi K, Soares A. Histological Features of Delayed Foreign Body Granuloma With Epithelioid Histiocyte Aggregation and Eosinophilic Reaction due to Hyaluronic Acid Injection. Case Reports in Dentistry 2024;2024(1) View
  15. Hong G, Hu H, Wan J, Chang K, Park Y, Vitale M, Damiani G, Yi K. How Should We Use Hyaluronidase for Dissolving Hyaluronic Acid Fillers?. Journal of Cosmetic Dermatology 2025;24(1) View
  16. Turcza J, Bartosinska J, Raczkiewicz D. Critical Ischemia Following Hyaluronic Acid Filler Injection: A Case Report. Journal of Clinical Medicine 2025;14(3):802 View
  17. Sarvepalli S, Pasika S, Vadarevu S, Bolla S, Bolla P. A comprehensive review on injectable hydrogels for cell therapy. Journal of Drug Delivery Science and Technology 2025;105:106648 View
  18. Sonnet M. Filler-Komplikationen und unerwünschte Ergebnisse auflösen. ästhetische dermatologie & kosmetologie 2025;17(1):10 View
  19. Barbery B, Lukesh N, Bachelder E, Ainslie K. Biodegradable Polymers for Application as Robust Immunomodulatory Biomaterial Carrier Systems. Small 2025 View
  20. Vansteelant G, D'Souza A. Facial Fillers and Surgical Rhinoplasty: Cross-Sectional Study. Facial Plastic Surgery 2025;41(06):856 View
  21. Yi K, Wan J, Yoon S. Considerations for Proper Use of Hyaluronidase in the Management of Hyaluronic Acid Fillers. Plastic and Reconstructive Surgery - Global Open 2025;13(3):e6566 View
  22. Al‐Zahawi S, Ehsani A, Jozdani T, Rahimnia A, Ehsani A, Razavi Z, Emadi S. The Demographics of Patients With Dermal Filler Complications. Journal of Cosmetic Dermatology 2025;24(3) View
  23. Hong G, Wan J, Yoon S, Wong S, Yi K. Conditions to Consider When Choosing Fillers. Journal of Cosmetic Dermatology 2025;24(3) View
  24. Sudharshan R, Davuluru S, Shen A, Gupta S, Saeedi N, Woodward J, Lee W, Kherani F, Foster J, Zhang-Nunes S. Identifying Minimum Single Dose of Recombinant Human Hyaluronidase for In Vitro Dissolution of Twenty-Two Hyaluronic Acid Fillers. Ophthalmic Plastic & Reconstructive Surgery 2025;41(6):657 View
  25. Kroumpouzos G, Silikovich F. Exploring Nonresponse to Botulinum Toxin in Aesthetics: Narrative Review of Key Trigger Factors and Effective Management Strategies. JMIR Dermatology 2025;8:e69960 View
  26. Swancutt M, Allard A, Ho A, Sloan S. Filling the Gap: Facial Anatomy and Safe Lower Lip Injection Practices. Journal of Clinical Medicine 2025;14(9):3214 View
  27. Silikovich F, Kroumpouzos G. Nonsurgical Rhinoplasty: A Modified Rino-4-Puntos Technique With Hyaluronic Acid Improves the Appearance of Nasal Septal Deviation. Plastic and Reconstructive Surgery - Global Open 2025;13(5):e6801 View
  28. Hong J, Park K. Dual Benefits of Calcium Hydroxyapatite Filler: A Prospective Study on Midface Volume Restoration and Skin Quality Enhancement. Journal of Cosmetic Dermatology 2025;24(6) View
  29. Ahmad R. A Comprehensive Evaluation of Dermal Fillers in Aesthetic Medicine: Safety, Efficacy, and Long-Term Outcomes. medtigo Journal of Medicine 2025;1(1):1 View
  30. Barbarino S, Khalifian S, Fezza J. EYE‐CODE Protocol for the Nonophthalmologist for Treatment of Retinal Artery Occlusion After Intra‐Arterial Injection of Soft‐Tissue Fillers: 2025 Update. Journal of Cosmetic Dermatology 2025;24(7) View
  31. Lu J, Zhao Z, Pan L, Wu H, Wang S, Tong X, Wu S. Hyaluronidase: structure, mechanism of action, diseases and therapeutic targets. Molecular Biomedicine 2025;6(1) View
  32. Safran T, Khalaf R, Metelitsa A, Woodward J, Nikolis A. Comparison of the Degradability of Hyaluronic Acid by Ovine and Recombinant Human Hyaluronidase. Aesthetic Surgery Journal 2025;45(10):1086 View
  33. Peng C, Xv W, Ao Y. A Review: Causes, Consequences, and Management Strategies of Facial Overfilling. Clinical, Cosmetic and Investigational Dermatology 2025;Volume 18:1857 View
  34. Shridharani S, Palm M, Jarmuz T, Somenek M, Nayak L, Saadat D, Indeyeva Y, Sykes J. Optimizing Aesthetic Facial Surgery Outcomes Following Minimally Invasive Treatments: Guidelines for Perioperative Management. Aesthetic Surgery Journal Open Forum 2025;7 View
  35. Karamık K, Yıldız A, Koraş Ö, Arslan M. Glanular Ischemia following Glans Penis Augmentation: A Rare Case Report. Urologia Internationalis 2025:1 View
  36. Tagaya M, Arai K, Kapoor K. Late Intervention Yet Successful Outcome with High-dose Pulsed Hyaluronidase for Forehead Filler Vascular Complication. Plastic and Reconstructive Surgery - Global Open 2025;13(9):e7087 View
  37. Cavallieri F, Munhoz G, de Almeida Balassiano L, Leroy A, Tembra M, Bortolato T, Cunha J, Meyer R, Balsanelli L, Ramos‐e‐Silva M. Management of Hyaluronic Acid Filler–Induced Refractory Sterile Abscess With Modified Munhoz‐Cavallieri Lavage Protocol: A Case Series. Journal of Cosmetic Dermatology 2025;24(9) View
  38. Moon D, Cho S, Ahn S. Managing residual volumes in penile girth enhancement with hyaluronic acid fillers: a case series and literature review. International Journal of Impotence Research 2025 View
  39. Andrade Hernández P. Angioedema associated with hyaluronic acid injection. Revista Alergia México 2025;72(3) View
  40. Velázquez Tafur L, Parra A, Martinez Amado A, Castelanich D, Acevedo A, Dicker V, Parra L. Rapid Access Algorithm for Managing Vascular Occlusion in Hyaluronic Acid Filler Procedures: A Narrative Review. Plastic and Aesthetic Nursing 2025;45(4):220 View
  41. Lemos A, Ranieri R, Araújo M, Camara J, Abrahão D, Muknicka D. Amaurose como evento adverso após aplicação de ácido hialurônico: Uma revisão narrativa da literatura. Research, Society and Development 2025;14(10):e23141049632 View
  42. Katarzyna Skibicka , Joanna Kryślak , Szymon Szabelski , Adam Solarz , Estera Graczyk , Maciej Sokołowski , Karolina Oskroba , Jakub Filip Turcza . FACIAL OVERFILLED SYNDROME: A REVIEW OF PATHOGENESIS, CLINICAL PRESENTATION AND MANAGEMENT. International Journal of Innovative Technologies in Social Science 2025;5(3(47)) View
  43. Hasanzadeh S, Farokh P, Hosseini G, Abbasian M, Etesami I, Zaresharifi S, Dadkhahfar S. Hyalase in Dermatology: Applications Beyond Filler Management. Journal of Cosmetic Dermatology 2025;24(11) View

Books/Policy Documents

  1. Go J, Lee W. Innovative Injectable Techniques in Minimally Invasive Aesthetics. View